Cardiac Glycosides & Antiarrhythmic Drugs: PPT/PDF Notes
Complete B.Pharm 5th Sem study material covering:
- Mechanisms of cardiac glycosides
- Vaughan Williams classification
- Clinical applications and dosage protocols
- 180+ MCQs with solutions
Keywords: cardiac glycosides pdf, antiarrhythmic drugs ppt, pharmacology notes, B.pharm 5th sem, digoxin therapy, Vaughan Williams classification
Comprehensive Guide to Cardiac Medications
Cardiac Glycosides (Digoxin)
- Mechanism: Na+/K+ ATPase inhibition
- Therapeutic Uses: CHF, atrial fibrillation
- Dosing: Loading dose 0.75-1.5 mg, Maintenance 0.125-0.25 mg/day
Antiarrhythmic Drug Classes
| Class | Action | Examples |
|---|---|---|
| IA | Moderate Na+ blockade | Quinidine |
| II | Beta blockade | Metoprolol |
| III | K+ channel blockade | Amiodarone |
Nursing Considerations
- Monitor serum potassium levels (3.5-5.0 mEq/L)
- Assess apical pulse before administration
- Watch for digitalis toxicity signs
- Calculate IV infusion rates accurately
Clinical Pearls
Digoxin Therapeutic Range:
• Serum concentration: 0.5-2 ng/mL
• Toxic >2.5 ng/mL
Amiodarone Loading:
• 150 mg IV over 10 min → 360 mg over 6 hr → 540 mg over 18 hr
Drug Interactions
- Diuretics → Hypokalemia risk
- Verapamil → Increased digoxin levels
- Warfarin → Enhanced anticoagulation
Course Details:
Subject: Pharmacology
Program: B.Pharm
Semester: 5th Semester
University: PCI Compliant
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