Tablet Excipients Handwritten Notes PDF | PPT
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Tablet Excipients: A Comprehensive Guide
Tablet excipients are inactive substances that are added to pharmaceutical formulations to aid in the manufacturing process and enhance the performance of the final product. They play a critical role in ensuring the stability, bioavailability, and efficacy of tablets. This blog provides a detailed explanation of tablet excipients, their types, functions, and applications in the pharmaceutical industry.
Types of Tablet Excipients
Tablet excipients can be classified into several categories based on their function:
- Binders: These are used to hold the ingredients together in a tablet, ensuring its mechanical strength.
- Fillers/Diluents: Fillers add bulk to the formulation, ensuring the correct dosage form and tablet size.
- Disintegrants: These help the tablet break down in the digestive system, releasing the active pharmaceutical ingredient (API) for absorption.
- Lubricants: Lubricants prevent the ingredients from sticking to the machinery during the manufacturing process and ensure smooth tablet ejection.
- Glidants: These improve the flow properties of the powder or granules, ensuring uniform tablet weight and content.
- Colorants and Flavors: Used to improve the appearance and taste of the tablet, especially in chewable or orally disintegrating tablets.
Functions of Tablet Excipients
Tablet excipients serve multiple functions in the development and manufacturing of tablets:
- Ensure the stability of the API by protecting it from environmental factors such as moisture and light.
- Improve the bioavailability of the drug by enhancing its dissolution and absorption.
- Facilitate the manufacturing process by improving the flowability, compressibility, and compactibility of the powder or granules.
- Enhance patient compliance by improving the taste, texture, and appearance of the tablet.
Conclusion
Tablet excipients are indispensable in the pharmaceutical industry. They not only aid in the manufacturing process but also ensure the quality, safety, and efficacy of the final product. By understanding the role and selection of excipients, pharmaceutical scientists can develop tablets that meet the desired therapeutic and regulatory requirements.
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