Introduction
Biopharmaceutics To Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of drugs from Non per oral extra-vascular routes,
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs.
Detailed Explanation
This document provides a comprehensive overview of biopharmaceutics and drug absorption mechanisms, focusing particularly on the gastrointestinal tract (GIT). It outlines the various factors that influence drug absorption through the GIT, as well as the absorption of drugs from non-oral extra-vascular routes. The content further delves into the distribution of drugs within tissue, highlighting tissue permeability and the binding characteristics of drugs. Other essential aspects covered include the apparent volume of drug distribution, the binding of drugs to plasma and tissue proteins, and the factors influencing protein-drug binding. The kinetics and clinical significance of protein binding of drugs are also discussed, providing a thorough understanding of this critical aspect of pharmacokinetics and drug distribution.
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