Biopharmaceutics and Pharmacokinetics (Unit:- 3)
Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model. (a) Intravenous Injection (Bolus) (b) Intravenous infusion and (c) Extra vascular administrations. Pharmacokinetics parameters - KE, t1/2, Vd, AUC, Ka, Clt and CLR- definitions, methods of eliminations, understanding of their significance and Application.
Detailed Explanation
This document provides an in-depth introduction to biopharmaceutics and pharmacokinetics, with a specific focus on various models and parameters involved in drug kinetics. It outlines definitions and applications of compartment and non-compartment models, as well as physiological models that explain the dynamics of drug absorption, distribution, metabolism, and excretion (ADME).
The content elaborates on the one compartment open model, detailing intravenous injection (bolus), intravenous infusion, and extra-vascular administrations. Key pharmacokinetic parameters such as KE (elimination rate constant), t1/2 (half-life), Vd (volume of distribution), AUC (area under the curve), Ka (absorption rate constant), Clt (total clearance), and CLR (renal clearance) are meticulously defined.
Methods of elimination and the significance of these pharmacokinetic parameters are discussed to provide a comprehensive understanding of their application in clinical settings. The document serves as an invaluable resource for those studying pharmacokinetics, offering clarity on the intricate processes governing drug behavior in the body.
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