Tablet: Industrial Pharmacy Handwritten Notes
Tablets: Introduction, ideal characteristics of tablets, classification of tablets. Excipients, fillers/diluents, binders, disintegrants, lubricants. Formulation of tablets, granulation methods, wet granulation (aqueous granulation technique), dry granulation (non-aqueous granulation technique), direct compression. Compression and processing problems, including capping, lamination, chipping, cracking, sticking, picking, binding, mottling, double impression, and tablet weight.
Problems and remedies for tablet coating, such as blistering, cratering, picking, pitting, blooming, blushing, colour variation, infilling, orange peel/roughness, cracking/splitting, and bridging. Tablet equipment, including rotary tablet press, press design and layout, tablet tooling (basics of tablet tooling, punch, die). Quality standards and compendial requirements, coating of tablets, coating formation, tablet coating in practice, problems associated with tablet coatings. In-process quality control tests for pharmaceutical tablets.
Questions Subject: Industrial pharmacy 1 Semester: Sixth sem, sem 6 Course: Bachelor of pharmacy, bpharm
Detailed Explanation
Tablets are a widely used dosage form in the pharmaceutical industry, known for their convenience and efficacy. This document provides an extensive overview of tablet formulation, manufacturing processes, and quality control tests. The introduction covers the ideal characteristics of tablets and their classification, highlighting the importance of excipients in the formulation process.
Granulation methods, including wet granulation (aqueous granulation technique), dry granulation (non-aqueous granulation technique), and direct compression, are discussed in detail. The document also addresses common compression and processing problems, such as capping, lamination, chipping, cracking, sticking, picking, binding, mottling, double impression, and tablet weight issues.
The section on tablet coating provides insights into various coating problems and their remedies. Issues like blistering, cratering, picking, pitting, blooming, blushing, colour variation, infilling, orange peel/roughness, cracking/splitting, and bridging are identified, along with solutions to address them. The document also covers tablet equipment, including rotary tablet presses, press design and layout, and tablet tooling (basics of tablet tooling, punch, die).
Quality standards and compendial requirements for tablets are discussed, along with the process of coating tablets and the problems associated with tablet coatings. In-process quality control tests for pharmaceutical tablets are essential to ensure their safety and efficacy. These tests include measures of tablet weight, hardness, friability, disintegration, and dissolution.
Overall, this comprehensive guide serves as a valuable resource for students and professionals in the pharmaceutical industry, providing essential knowledge for the development and manufacturing of high-quality tablets.
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