Pharmacognosy 2 Unit 4: Industrial Phytoconstituents (Handwritten Notes)
Download B.Pharm Sem 5 PDF notes covering industrial production, estimation methods, and therapeutic utilization of key phytoconstituents. Includes detailed protocols for Taxol, Artemisinin, Digoxin, and other vital plant-derived compounds. Perfect for pharmacy students seeking handwritten notes, PPT presentations, and study materials for Pharmacognosy 2.
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Industrial Production & Application of Medicinal Phytoconstituents
Key Compounds and Processes
- Artemisinin:
- Production: Cell culture techniques in Artemisia annua
- Estimation: HPLC with UV detection
- Use: WHO-approved malaria treatment
- Taxol (Paclitaxel):
- Production: Plant cell fermentation of Taxus species
- Estimation: LC-MS quantification
- Use: Breast and ovarian cancer chemotherapy
- Digoxin:
- Production: Digitalis lanata cultivation & extraction
- Estimation: Radioimmunoassay methods
- Use: Congestive heart failure treatment
Industrial Production Techniques
- Bioreactor-based plant cell cultures
- Supercritical fluid extraction systems
- Enzyme-assisted biosynthesis
- Genetic engineering of metabolic pathways
Quality Control Methods
- Chromatographic techniques (HPLC, TLC, GC)
- Spectroscopic analysis (NMR, MS)
- Biological standardization methods
- Microbiological assay protocols
Course Relevance
Essential study material for B.Pharm Semester 5 students covering:
- Current Good Manufacturing Practices (cGMP) for plant drugs
- Scale-up challenges in phytopharmaceuticals
- IPR considerations in plant-based drug production
- Case studies of commercial phytoconstituents
700+ words detailed notes covering production flowcharts, yield optimization strategies, and global market requirements for plant-derived active pharmaceutical ingredients (APIs).
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