Medicinal Chemistry 2: Unit 1 || Handwritten Notes
Download detailed handwritten notes on Medicinal Chemistry 2: Unit 1, covering topics such as Antihistaminic Agents, H1–antagonists, H2-antagonists, Gastric Proton Pump Inhibitors, and Anti-neoplastic Agents. These notes are essential for students studying pharmaceutical chemistry and preparing for exams.
Keywords: download PDF, handwritten notes, antihistaminic agents, H1-antagonists, H2-antagonists, proton pump inhibitors, anti-neoplastic agents, pharmaceutical chemistry.
Medicinal Chemistry 2: Unit 1 – A Comprehensive Guide
Medicinal Chemistry 2: Unit 1 focuses on the study of Antihistaminic Agents, H1–antagonists, H2-antagonists, Gastric Proton Pump Inhibitors, and Anti-neoplastic Agents. This unit is a critical part of the pharmaceutical chemistry curriculum, providing students with an in-depth understanding of the chemical structures, mechanisms of action, and therapeutic applications of these drugs.
Antihistaminic Agents
Histamine is a biogenic amine involved in various physiological processes, including immune responses and gastric acid secretion. Antihistaminic agents are drugs that block the action of histamine by binding to its receptors. These agents are classified into H1–antagonists and H2-antagonists based on their receptor specificity.
H1–antagonists
H1–antagonists are primarily used to treat allergic reactions and include drugs such as:
- Diphenhydramine hydrochloride*
- Dimenhydrinate
- Doxylamine succinate
- Clemastine fumarate
- Diphenylphyraline hydrochloride
- Tripelenamine hydrochloride
- Chlorcyclizine hydrochloride
- Meclizine hydrochloride
- Buclizine hydrochloride
- Chlorpheniramine maleate
- Triprolidine hydrochloride*
- Phenidamine tartarate
- Promethazine hydrochloride*
- Trimeprazine tartrate
- Cyproheptadine hydrochloride
- Azatidine maleate
- Astemizole
- Loratadine
- Cetirizine
- Levocetrazine
- Cromolyn sodium
H2-antagonists
H2-antagonists are used to reduce gastric acid secretion and include drugs such as:
- Cimetidine*
- Famotidine
- Ranitidine
Gastric Proton Pump Inhibitors
Proton pump inhibitors (PPIs) are used to treat gastroesophageal reflux disease (GERD) and peptic ulcers. Examples include:
- Omeprazole
- Lansoprazole
- Rabeprazole
- Pantoprazole
Anti-neoplastic Agents
Anti-neoplastic agents are used in the treatment of cancer and are classified into:
- Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa
- Antimetabolites: Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine
- Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin
- Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate
- Miscellaneous: Cisplatin, Mitotane
These handwritten notes provide a detailed explanation of the chemical structures, mechanisms of action, and therapeutic uses of these drugs, making them an invaluable resource for students and professionals in the field of pharmaceutical chemistry.
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