Heparin as Anticoagulant: Handwritten Notes
Download comprehensive handwritten notes explaining Heparin's mechanism of action, clinical applications, and monitoring parameters. Ideal for medical students and healthcare professionals seeking PDF notes, PPT slides, and study materials on anticoagulant therapy.
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Heparin as Anticoagulant: Detailed Pharmacology
Introduction to Heparin
Heparin is a naturally occurring glycosaminoglycan used clinically as an anticoagulant. These notes cover its complete pharmacology including:
Mechanism of Action
- Binds to antithrombin III (AT III)
- Accelerates inhibition of clotting factors (IIa, Xa)
- Prevents conversion of fibrinogen to fibrin
- Inhibits platelet aggregation
Clinical Applications
Prophylaxis and treatment
Unstable angina/NSTEMI management
Dialysis and bypass surgery
Monitoring Parameters
| Test | Normal Range | Therapeutic Range |
|---|---|---|
| aPTT | 25-35 seconds | 60-80 seconds |
| Anti-Xa assay | - | 0.3-0.7 IU/mL |
Adverse Effects
⚠️ Heparin-Induced Thrombocytopenia (HIT)
⚠️ Osteoporosis (long-term use)
⚠️ Hemorrhage risk
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