Problems of Tablet Manufacturing: PDF/PPT
In the normal process of developing formulations and in the routine manufacture of tablets, various defects are observed. Sometimes, the source of the problem or the defect is the formulation, the compression equipment, or a combination of the two.
Some defects are noticed immediately during manufacturing but others may be noticed during storage, as in the case of capping.
Capping and Lamination: - Capping is defined as the partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet. - Lamination is the separation of a tablet into two or more distinct layers. These processing problems are readily apparent immediately after compression or may occur hours or even days later. Subjecting tablets to the friability test is the quickest way of revealing such problems.
Causes of Capping and Lamination: - Air entrapment: Due to the air-entrapment in a compact during compression and subsequent expansion of the tablet on ejection of a tablet from a die.
Subject: Industrial Pharmacy 1 Semester: Sixth sem, sem 6 Course: Bachelor of Pharmacy, BPharm
Detailed Explanation
During the development and routine manufacture of tablets, various defects can arise. These defects may be due to formulation issues, compression equipment problems, or a combination of both. Some defects are immediately noticeable during manufacturing, while others may only become apparent during storage, such as capping.
Capping is the partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet. Lamination, on the other hand, refers to the separation of a tablet into two or more distinct layers. These problems can appear immediately after compression or may occur hours or even days later.
Subjecting tablets to a friability test is the quickest way to reveal such problems. One of the primary causes of capping and lamination is air entrapment. During compression, air can become trapped in the compact, leading to expansion and separation of the tablet upon ejection from the die.
Understanding these issues and their causes is crucial for improving tablet formulation and manufacturing processes, ensuring the production of high-quality and stable tablet products that meet regulatory standards.
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