Medicinal Chemistry 2: Unit 5 || Handwritten Notes
Download detailed handwritten notes on Medicinal Chemistry 2: Unit 5, covering topics such as Antidiabetic Agents, Insulin and its Preparations, Sulfonylureas, Biguanides, Thiazolidinediones, Meglitinides, Glucosidase Inhibitors, and Local Anesthetics. These notes are essential for students studying pharmaceutical chemistry and preparing for exams.
Keywords: download PDF, handwritten notes, antidiabetic agents, insulin, sulfonylureas, biguanides, thiazolidinediones, meglitinides, glucosidase inhibitors, local anesthetics, pharmaceutical chemistry.
Medicinal Chemistry 2: Unit 5 – A Comprehensive Guide
Medicinal Chemistry 2: Unit 5 focuses on the study of Antidiabetic Agents and Local Anesthetics. This unit is a critical part of the pharmaceutical chemistry curriculum, providing students with an in-depth understanding of the chemical structures, mechanisms of action, and therapeutic applications of these drugs.
Antidiabetic Agents
Antidiabetic agents are used to manage blood glucose levels in patients with diabetes. They are classified into several categories:
Insulin and its Preparations
Insulin is a hormone that regulates blood glucose levels. Various insulin preparations are available, including rapid-acting, short-acting, intermediate-acting, and long-acting insulins.
Sulfonylureas
Sulfonylureas stimulate insulin secretion from pancreatic beta cells. Examples include:
- Tolbutamide*
- Chlorpropamide
- Glipizide
- Glimepiride
Biguanides
Biguanides reduce glucose production in the liver and improve insulin sensitivity. The most commonly used biguanide is:
- Metformin
Thiazolidinediones
Thiazolidinediones improve insulin sensitivity in peripheral tissues. Examples include:
- Pioglitazone
- Rosiglitazone
Meglitinides
Meglitinides stimulate insulin secretion. Examples include:
- Repaglinide
- Nateglinide
Glucosidase Inhibitors
Glucosidase inhibitors delay carbohydrate absorption in the intestine. Examples include:
- Acarbose
- Voglibose
Local Anesthetics
Local anesthetics are used to block pain sensation in a specific area of the body. The structure-activity relationship (SAR) of local anesthetics is discussed, along with the following categories:
Benzoic Acid Derivatives
Examples include:
- Cocaine
- Hexylcaine
- Meprylcaine
- Cyclomethycaine
- Piperocaine
Amino Benzoic Acid Derivatives
Examples include:
- Benzocaine*
- Butamben
- Procaine*
- Butacaine
- Propoxycaine
- Tetracaine
- Benoxinate
Lidocaine/Anilide Derivatives
Examples include:
- Lignocaine
- Mepivacaine
- Prilocaine
- Etidocaine
Miscellaneous
Examples include:
- Phenacaine
- Diperodon
- Dibucaine*
These handwritten notes provide a detailed explanation of the chemical structures, mechanisms of action, and therapeutic uses of these drugs, making them an invaluable resource for students and professionals in the field of pharmaceutical chemistry.
Info!
If you are the copyright owner of this document and want to report it, please visit the copyright infringement notice page to submit a report.
