Medicinal chemistry 2 Unit:- 5

Medicinal Chemistry 2: Unit 5 || Handwritten Notes

Download detailed handwritten notes on Medicinal Chemistry 2: Unit 5, covering topics such as Antidiabetic Agents, Insulin and its Preparations, Sulfonylureas, Biguanides, Thiazolidinediones, Meglitinides, Glucosidase Inhibitors, and Local Anesthetics. These notes are essential for students studying pharmaceutical chemistry and preparing for exams.

Keywords: download PDF, handwritten notes, antidiabetic agents, insulin, sulfonylureas, biguanides, thiazolidinediones, meglitinides, glucosidase inhibitors, local anesthetics, pharmaceutical chemistry.

Medicinal Chemistry 2: Unit 5 – A Comprehensive Guide

Medicinal Chemistry 2: Unit 5 focuses on the study of Antidiabetic Agents and Local Anesthetics. This unit is a critical part of the pharmaceutical chemistry curriculum, providing students with an in-depth understanding of the chemical structures, mechanisms of action, and therapeutic applications of these drugs.

Antidiabetic Agents

Antidiabetic agents are used to manage blood glucose levels in patients with diabetes. They are classified into several categories:

Insulin and its Preparations

Insulin is a hormone that regulates blood glucose levels. Various insulin preparations are available, including rapid-acting, short-acting, intermediate-acting, and long-acting insulins.

Sulfonylureas

Sulfonylureas stimulate insulin secretion from pancreatic beta cells. Examples include:

  • Tolbutamide*
  • Chlorpropamide
  • Glipizide
  • Glimepiride

Biguanides

Biguanides reduce glucose production in the liver and improve insulin sensitivity. The most commonly used biguanide is:

  • Metformin

Thiazolidinediones

Thiazolidinediones improve insulin sensitivity in peripheral tissues. Examples include:

  • Pioglitazone
  • Rosiglitazone

Meglitinides

Meglitinides stimulate insulin secretion. Examples include:

  • Repaglinide
  • Nateglinide

Glucosidase Inhibitors

Glucosidase inhibitors delay carbohydrate absorption in the intestine. Examples include:

  • Acarbose
  • Voglibose

Local Anesthetics

Local anesthetics are used to block pain sensation in a specific area of the body. The structure-activity relationship (SAR) of local anesthetics is discussed, along with the following categories:

Benzoic Acid Derivatives

Examples include:

  • Cocaine
  • Hexylcaine
  • Meprylcaine
  • Cyclomethycaine
  • Piperocaine

Amino Benzoic Acid Derivatives

Examples include:

  • Benzocaine*
  • Butamben
  • Procaine*
  • Butacaine
  • Propoxycaine
  • Tetracaine
  • Benoxinate

Lidocaine/Anilide Derivatives

Examples include:

  • Lignocaine
  • Mepivacaine
  • Prilocaine
  • Etidocaine

Miscellaneous

Examples include:

  • Phenacaine
  • Diperodon
  • Dibucaine*

These handwritten notes provide a detailed explanation of the chemical structures, mechanisms of action, and therapeutic uses of these drugs, making them an invaluable resource for students and professionals in the field of pharmaceutical chemistry.

Info!
If you are the copyright owner of this document and want to report it, please visit the copyright infringement notice page to submit a report.

Post a Comment