Antiarrhythmic Drugs: PPT/PDF Notes - B.Pharm 5th Sem
Complete pharmacology study material covering antiarrhythmic drug classification, mechanisms, and nursing implications. Includes:
- Vaughan Williams classification system
- Cardiac action potential phases
- Dosage calculation methods
- Nursing interventions
- 200+ MCQs with answers
Keywords: antiarrhythmic drugs ppt, pharmacology notes pdf, B.pharm 5th sem notes, cardiac arrhythmia management, nursing drug calculations, Vaughan Williams classification pdf
Comprehensive Guide to Antiarrhythmic Drugs
Pharmacological Management of Arrhythmias
Antiarrhythmic drugs are classified using the Vaughan Williams system based on their effects on cardiac action potentials:
Class I: Sodium Channel Blockers
- IA: Quinidine, Procainamide - Moderate Na+ blockade
- IB: Lidocaine, Mexiletine - Fast dissociation
- IC: Flecainide, Propafenone - Strong Na+ blockade
Class II: Beta Blockers
Propranolol, Metoprolol - Reduce sympathetic stimulation
Class III: Potassium Channel Blockers
Amiodarone, Sotalol - Prolong action potential duration
Class IV: Calcium Channel Blockers
Verapamil, Diltiazem - Affect AV node conduction
Nursing Implications
- Monitor ECG for QT prolongation
- Assess liver/kidney function for drug metabolism
- Educate patients about drug-food interactions
- Calculate IV doses carefully using body weight
Dosage Calculations
Example: Loading dose of Amiodarone = 5 mg/kg IV over 20-120 min
Maintenance: 0.5-1 mg/min continuous infusion
Clinical Considerations
| Drug | Half-life | Key Monitoring |
|---|---|---|
| Digoxin | 36-48h | Serum K+ levels |
| Amiodarone | 25-110 days | Thyroid function |
Complete with 35+ detailed diagrams of cardiac action potentials and 10 case studies with solutions.
Course Info:
Subject: Pharmacology
Program: B.Pharm (Pharmacy)
Semester: 5th Semester
Content: Theory + Practical Guidelines
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