Acetate Pathway Notes - B.Pharm Sem 5 Pharmacognosy
Download PDF Notes covering:
- Fatty acid biosynthesis mechanism
- Polyketide and prostaglandin formation
- Enzyme functions in acetate metabolism
- Palmitic acid synthesis process
- Clinical applications of acetate pathway
Keywords: Acetate pathway PDF, Pharmacognosy notes download, B.Pharm sem 5 PPT, Fatty acid biosynthesis notes, Polyketide formation study material
Comprehensive Guide to Acetate Pathways in Pharmacognosy
1. Biosynthesis Process
The acetate pathway plays a crucial role in forming various phytoconstituents including:
- Fatty acids (palmitic acid, stearic acid)
- Polyketides (tetracyclines, aflatoxins)
- Prostaglandins (inflammatory mediators)
2. Key Enzymes & Reactions
The process begins with acetyl-CoA carboxylation:
- Acetyl-CoA Carboxylase: Converts acetyl-CoA to malonyl-CoA
- ATP Utilization: Energy source for carboxylation
- Reduction Cycle: NADH-dependent reactions forming butyryl-ALP
3. Fatty Acid Synthesis
Critical steps in chain elongation:
- Malonyl-CoA coupling with fatty acid residues
- 2-carbon unit addition per cycle
- Palmitic acid (C16) as primary end product
4. Clinical Applications
Understanding acetate pathways helps in:
- Antibiotic production (tetracyclines)
- Lipid metabolism regulation
- Mycotoxin research (aflatoxins)
This 60-page guide includes detailed biochemical pathways, enzyme mechanisms, and pharmaceutical applications essential for fifth semester pharmacy students.
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